It's the Key Achievement, Description, Unlock & Secret Number | Binding of Isaac Wiki

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Binding of Isaac Achievement: It's the Key

Achievements

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Description	Unlocked a new item.
Unlock	Defeat The Lamb without taking hearts, coins, and bombs through an entire run
In-Game Secret Number	327
Platforms	All
DLC Required	Added in Afterbirth+
Achievement Description

Description: Unlocked a new item.
Unlock: Complete a floor after Basement I, start-to-finish, with only half a heart of health (can use The Lost)
In-Game Secret Number: 329

Living on the Edge

Description: Unlocked a new item.
Unlock: Acquire Blood Clot 10 times
In-Game Secret Number: 377

Description: Unlocked a new item.
Unlock: Destroy 5 rainbow poops
In-Game Secret Number: 353
PS4 344

Description: Unlocked a new item.
Unlock: Defeat all 5 Harbingers
In-Game Secret Number: 372
PS4 363

Description: Unlocked a new item.
Unlock: Defeat Ultra Greedier as Eden
In-Game Secret Number: 303

Description: Unlocked a new co-player baby.
Unlock: Defeat Delirium as ???
In-Game Secret Number: 286

Description: Unlocked a new item.
Unlock: It's complicated
In-Game Secret Number: 391

Description: Unlocked super special rocks.
Unlock: Get a 5-win streak, using a different character for each win
In-Game Secret Number: 323

5 Nights at Mom's

Description: Unlocked a new item.
Unlock: Defeat Ultra Greed as Apollyon
In-Game Secret Number: 316

Description: Unlocked a new item.
Unlock: Defeat Delirium as Isaac
In-Game Secret Number: 282

Description: Unlocked a new item.
Unlock: Defeat Delirium as Eden
In-Game Secret Number: 289

Description: Unlocked a new item.
Unlock: Take 25 devil deals
In-Game Secret Number: 376

Description: Unlocked a new item.
Unlock: Complete the Boss Rush as Apollyon
In-Game Secret Number: 314

Locust of Conquest

Description: Unlocked a new item.
Unlock: Reset 7 times in a row
In-Game Secret Number: 328

Description: Unlocked a new item.
Unlock: Take 25 items from Angel rooms
In-Game Secret Number: 380

Description: Unlocked a new item.
Unlock: Pick up 5 familiars in a single run
In-Game Secret Number: 355
PS4 346

Description: Unlocked a new item.
Unlock: Purchase from shops 50 times
In-Game Secret Number: 364
PS4 355

Description: Unlocked a new item.
Unlock: Defeat Delirium as The Lost
In-Game Secret Number: 293

Description: Unlocked a new item.
Unlock: Defeat Mom's Heart or It Lives! on hard modeas The Forgotten
In-Game Secret Number: 392

Description: Unlocked the power of RERUN.
Unlock: Complete 3 Victory Laps and start a 4th
In-Game Secret Number: 337

Description: Unlocked a new item.
Unlock: Defeat Delirium as Cain
In-Game Secret Number: 284

Description: Unlocked a new character.
Unlock: Defeat Mega Satan for the 1st time
In-Game Secret Number: 340

Description: Unlocked a new item.
Unlock: Defeat The Lamb as The Forgotten
In-Game Secret Number: 396

Description: Unlocked a new item.
Unlock: Defeat Delirium as Lazarus
In-Game Secret Number: 291

Compound Fracture

Description: Unlocked new enemies!
Unlock: Defeat The Lamb for the 1st time
In-Game Secret Number: 348

The gate is open!

Description: Unlocked a new item.
Unlock: Defeat Isaac as The Forgotten
In-Game Secret Number: 393

Description: Unlocked a new item.
Unlock: Defeat Ultra Greedier as The Lost
In-Game Secret Number: 307

Dad's Lost Coin

Description: Unlocked a new co-player baby.
Unlock: Earn all Hard Mode Completion Marks as The Forgotten
In-Game Secret Number: 402

Description: Unlocked a new item.
Unlock: Defeat Delirium as Eve
In-Game Secret Number: 288

Description: Unlocked a new starting item.
Unlock: Complete challenge #32
In-Game Secret Number: 332

MaggyNow Holds a Pill!