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Welcome to The Binding of Isaac achievement guide. Click on an achievement to learn more.
| The Mind | Unlocked a new item. | Defeat Satan as The Lost | 130 |
| The Body | Unlocked a new item. | Defeat ??? as The Lost | 131 |
| The Soul | Unlocked a new item. | Defeat The Lamb as The Lost | 132 |
| The D100 | Unlocked a new item. | Complete the Boss Rush as The Lost | 133 |
| Blue Map | Unlocked a new item. | Donate 10 coins to the Donation Machine | 134 |
| There's Options | Unlocked a new item. | Donate 50 coins to the Donation Machine | 135 |
| Black Candle | Unlocked a new item | Donate 150 coins to the Donation Machine | 136 |
| Red Candle | Unlocked a new item. | Donate 400 coins to the Donation Machine | 137 |
| Stop Watch | Unlocked a new item | Donate 999 coins to the Donation Machine | 138 |
| Wire Coat Hanger | Unlocked a new item. | Defeat Mom's Heart 4 times | 139 |
| Ipecac | Unlocked a new item. | Defeat Mom's Heart 6 times | 140 |
| Experimental Treatment | Unlocked a new item. | Defeat Mom's Heart 7 times | 141 |
| Krampus | Unlocked another miniboss! | Take 20 items from devil rooms | 142 |
| Head of Krampus | Unlocked a new item. | Defeat Krampus for the 1st time | 143 |
| Super Meat Boy | Built him out of meat cubes. | Make a Super Meat Boy by picking up 4 Cubes of Meat in one run; see methods to create a Super Meat Boy | 144 |
| Butter Bean | Unlocked a new item. | Destroy 100 poops | 145 |
| Little Baggy | Unlocked a new item. | Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball | 146 |
| Blood Bag | Unlocked a new item. | Use the Blood Donation Machine 30 times | 147 |
| The D4 | Unlocked a new item. | Blow up 30 arcade machines | 148 |
| Missing Poster | Unlocked a new item. | Defeat The Lamb as Isaac | 149 |
| Rubber Cement | Unlocked a new item. | Defeat Mom's Heart 2 times | 150 |
| Store Upgrade lv.1 | Donated 20 pennies to the shop. | Donate 20 coins to the Donation Machine | 151 |
| Store Upgrade lv.2 | Donated 100 pennies to the shop. | Donate 100 coins to the Donation Machine | 152 |
| Store Upgrade lv.3 | Donated 200 pennies to the shop. | Donate 200 coins to the Donation Machine | 153 |
| Store Upgrade lv.4 | Donated 600 pennies to the shop. | Donate 600 coins to the Donation Machine | 154 |
| Angels | They are waiting. | Complete Chapter 6 | 155 |
| Godhead | Unlocked a new item. | Removed in Afterbirth: Beat Mom's Heart, Isaac, Satan, ???, and The Lamb and complete the Boss Rushon hard mode as The Lost Added in Afterbirth: Earn all 9 Completion Marks on hard mode as The Lost | 156 |
| Darkness Falls | Unlocked Challenge #4. | Defeat Mom's Heart 11 times | 157 |
| The Tank | Unlocked Challenge #5. | Have 7 or more heart containers at one time | 158 |
| Solar System | Unlocked Challenge #6. | Defeat Mom's Heart 3 times | 159 |
| Suicide King | Unlocked Challenge #7. | Defeat Mom's Heart 11 times | 160 |
| Cat Got Your Tongue | Unlocked Challenge #8. | Become Guppy (Collect 3 Guppy Items) | 161 |
| Demo Man | Unlocked Challenge #9. | Defeat Mom's Heart 9 times | 162 |
| Cursed! | Unlocked Challenge #10. | Have 7 or more heart containers at one time | 163 |
| Glass Cannon | Unlocked Challenge #11. | Beat challenge #19 and defeat Lokii for the 1st time | 164 |
| The Family Man | Unlocked Challenge #19. | Pick up both Key pieces from the Angels in one run | 165 |
| Purist | Unlocked Challenge #20. | Defeat Mom for the first time | 166 |
| Lost Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as Isaac | 167 |
| Cute Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as Magdalene | 168 |
| Crow Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as Eve | 169 |
| Shadow Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as Judas | 170 |
| Glass Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as Cain | 171 |
| Wrapped Baby | Unlocked a new co-player baby. | Removed in Afterbirth+: Defeat Mom's Heart on hard mode as Azazel Added in Afterbirth+: Defeat Mom's Heart on hard mode as Lazarus | 172 |
| Begotten Baby | Unlocked a new co-player baby. | Removed in Afterbirth+: Defeat Mom's Heart on hard mode as Lazarus Added in Afterbirth+: Defeat Mom's Heart on hard mode as Azazel | 173 |
| Dead Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as ??? | 174 |
| -0- Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as The Lost | 175 |
| Glitch Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as Eden | 176 |
| Fighting Baby | Unlocked a new co-player baby. | Defeat Mom's Heart on hard mode as Samson | 177 |
| Lord of the Flies | You became Lord of the Flies. | Become Lord of the Flies | 178 |
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