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Welcome to The Binding of Isaac achievement guide. Click on an achievement to learn more.

https://bindingofisaacwiki.com/i/q/bindingofisaacwiki__achievements?c=None&a=&f=&_n=25
Description
Unlock
In-Game Secret Number
The Mind Unlocked a new item. Defeat Satan as The Lost 130
The Body Unlocked a new item. Defeat ??? as The Lost 131
The Soul Unlocked a new item. Defeat The Lamb as The Lost 132
The D100 Unlocked a new item. Complete the Boss Rush as The Lost 133
Blue Map Unlocked a new item. Donate 10 coins to the Donation Machine 134
There's Options Unlocked a new item. Donate 50 coins to the Donation Machine 135
Black Candle Unlocked a new item Donate 150 coins to the Donation Machine 136
Red Candle Unlocked a new item. Donate 400 coins to the Donation Machine 137
Stop Watch Unlocked a new item Donate 999 coins to the Donation Machine 138
Wire Coat Hanger Unlocked a new item. Defeat Mom's Heart 4 times 139
Ipecac Unlocked a new item. Defeat Mom's Heart 6 times 140
Experimental Treatment Unlocked a new item. Defeat Mom's Heart 7 times 141
Krampus Unlocked another miniboss! Take 20 items from devil rooms 142
Head of Krampus Unlocked a new item. Defeat Krampus for the 1st time 143
Super Meat Boy Built him out of meat cubes. Make a Super Meat Boy by picking up 4 Cubes of Meat in one run; see methods to create a Super Meat Boy 144
Butter Bean Unlocked a new item. Destroy 100 poops 145
Little Baggy Unlocked a new item. Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball 146
Blood Bag Unlocked a new item. Use the Blood Donation Machine 30 times 147
The D4 Unlocked a new item. Blow up 30 arcade machines 148
Missing Poster Unlocked a new item. Defeat The Lamb as Isaac 149
Rubber Cement Unlocked a new item. Defeat Mom's Heart 2 times 150
Store Upgrade lv.1 Donated 20 pennies to the shop. Donate 20 coins to the Donation Machine 151
Store Upgrade lv.2 Donated 100 pennies to the shop. Donate 100 coins to the Donation Machine 152
Store Upgrade lv.3 Donated 200 pennies to the shop. Donate 200 coins to the Donation Machine 153
Store Upgrade lv.4 Donated 600 pennies to the shop. Donate 600 coins to the Donation Machine 154
Angels They are waiting. Complete Chapter 6 155
Godhead Unlocked a new item. Removed in Afterbirth: Beat Mom's Heart, Isaac, Satan, ???, and The Lamb and complete the Boss Rushon hard mode as The Lost
Added in Afterbirth: Earn all 9 Completion Marks on hard mode as The Lost
156
Darkness Falls Unlocked Challenge #4. Defeat Mom's Heart 11 times 157
The Tank Unlocked Challenge #5. Have 7 or more heart containers at one time 158
Solar System Unlocked Challenge #6. Defeat Mom's Heart 3 times 159
Suicide King Unlocked Challenge #7. Defeat Mom's Heart 11 times 160
Cat Got Your Tongue Unlocked Challenge #8. Become Guppy (Collect 3 Guppy Items) 161
Demo Man Unlocked Challenge #9. Defeat Mom's Heart 9 times 162
Cursed! Unlocked Challenge #10. Have 7 or more heart containers at one time 163
Glass Cannon Unlocked Challenge #11. Beat challenge #19 and defeat Lokii for the 1st time 164
The Family Man Unlocked Challenge #19. Pick up both Key pieces from the Angels in one run 165
Purist Unlocked Challenge #20. Defeat Mom for the first time 166
Lost Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as Isaac 167
Cute Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as Magdalene 168
Crow Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as Eve 169
Shadow Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as Judas 170
Glass Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as Cain 171
Wrapped Baby Unlocked a new co-player baby. Removed in Afterbirth+: Defeat Mom's Heart on hard mode as Azazel
Added in Afterbirth+: Defeat Mom's Heart on hard mode as Lazarus
172
Begotten Baby Unlocked a new co-player baby. Removed in Afterbirth+: Defeat Mom's Heart on hard mode as Lazarus
Added in Afterbirth+: Defeat Mom's Heart on hard mode as Azazel
173
Dead Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as ??? 174
-0- Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as The Lost 175
Glitch Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as Eden 176
Fighting Baby Unlocked a new co-player baby. Defeat Mom's Heart on hard mode as Samson 177
Lord of the Flies You became Lord of the Flies. Become Lord of the Flies 178