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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
| XXXXXXXXL | 21 | 3 Red Hearts | Gold Heart | |||
| SPEED! | 22 | 3 Red Hearts | Get out of Jail Free Card | |||
| Blue Bomber | 23 | 3 Soul Hearts, Blindfolded | Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega | Gold Bomb | ||
| PAY TO PLAY | 24 | 3 Red Hearts | Money = Power, Sack of Pennies, 50 coins | 2 new pills | ||
| Have a Heart | 25 | 1 Red Heart, 11 Empty Hearts | Charm of the Vampire | 2 new pills | ||
| I RULE! | 26 | 3 Red Hearts | The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield | Poker Chip | ||
| BRAINS! | 27 | 3 Soul Hearts, Blindfolded | 3 Bob's Brain, Thunder Thighs | Stud Finder | ||
| PRIDE DAY! | 28 | 3 Red Hearts | 3 Dollar Bill, Rainbow Baby, Rainbow Worm | D8 | ||
| Onan's Streak | 29 | 1 Red Heart | The Book of Belial, Chocolate Milk | Kidney Stone | ||
| The Guardian | 30 | 3 Red Hearts, Blindfolded | Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny | Blank Rune |
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