Binding of Isaac Wiki
Binding of Isaac Wiki
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Afterbirth Challenges

Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Hearts (with Amounts)
XXXXXXXXL 21 3 Red Hearts Gold Heart
SPEED! 22 3 Red Hearts Get out of Jail Free Card
Blue Bomber 23 3 Soul Hearts, Blindfolded Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega Gold Bomb
PAY TO PLAY 24 3 Red Hearts Money = Power, Sack of Pennies, 50 coins 2 new pills
Have a Heart 25 1 Red Heart, 11 Empty Hearts Charm of the Vampire 2 new pills
I RULE! 26 3 Red Hearts The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield Poker Chip
BRAINS! 27 3 Soul Hearts, Blindfolded 3 Bob's Brain, Thunder Thighs Stud Finder
PRIDE DAY! 28 3 Red Hearts 3 Dollar Bill, Rainbow Baby, Rainbow Worm D8
Onan's Streak 29 1 Red Heart The Book of Belial, Chocolate Milk Kidney Stone
The Guardian 30 3 Red Hearts, Blindfolded Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny Blank Rune