Cookies on this website are used to improve your experience and display advertising. You agree to the use of cookies by continuing to use this website. Our Privacy Policy contains more information about how we use cookies.
Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
| Solar System | 6 | 3 Red Hearts, Blindfolded | Distant Admiration, Forever Alone, Halo of Flies, Transcendence | Rune of Perthro | ||
| Cat Got Your Tongue | 8 | 3 Soul Hearts, 3 Black Hearts, Blindfolded | Guppy's Hair Ball, Guppy's Head, Guppy's Tail | Rune of Algiz | ||
| Beans! | 13 | 3 Red Hearts, Blindfolded | 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro | Burnt Penny | ||
| The Family Man | 19 | 3 Red Hearts, Blindfolded | BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy | Epic Fetus | ||
| Blue Bomber | 23 | 3 Soul Hearts, Blindfolded | Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega | Gold Bomb | ||
| BRAINS! | 27 | 3 Soul Hearts, Blindfolded | 3 Bob's Brain, Thunder Thighs | Stud Finder | ||
| The Guardian | 30 | 3 Red Hearts, Blindfolded | Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny | Blank Rune |
Cookies on this website are used to improve your experience and display advertising. You agree to the use of cookies by continuing to use this website. Our Privacy Policy contains more information about how we use cookies.