Binding of Isaac Wiki
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Blindfolded Challenges

Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Hearts (with Amounts)
Solar System 6 3 Red Hearts, Blindfolded Distant Admiration, Forever Alone, Halo of Flies, Transcendence Rune of Perthro
Cat Got Your Tongue 8 3 Soul Hearts, 3 Black Hearts, Blindfolded Guppy's Hair Ball, Guppy's Head, Guppy's Tail Rune of Algiz
Beans! 13 3 Red Hearts, Blindfolded 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro Burnt Penny
The Family Man 19 3 Red Hearts, Blindfolded BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy Epic Fetus
Blue Bomber 23 3 Soul Hearts, Blindfolded Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega Gold Bomb
BRAINS! 27 3 Soul Hearts, Blindfolded 3 Bob's Brain, Thunder Thighs Stud Finder
The Guardian 30 3 Red Hearts, Blindfolded Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny Blank Rune