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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Solar System | 6 | 3 Red Hearts, Blindfolded | Distant Admiration, Forever Alone, Halo of Flies, Transcendence | Rune of Perthro | ||
Cat Got Your Tongue | 8 | 3 Soul Hearts, 3 Black Hearts, Blindfolded | Guppy's Hair Ball, Guppy's Head, Guppy's Tail | Rune of Algiz | ||
Beans! | 13 | 3 Red Hearts, Blindfolded | 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro | Burnt Penny | ||
The Family Man | 19 | 3 Red Hearts, Blindfolded | BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy | Epic Fetus | ||
Blue Bomber | 23 | 3 Soul Hearts, Blindfolded | Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega | Gold Bomb | ||
BRAINS! | 27 | 3 Soul Hearts, Blindfolded | 3 Bob's Brain, Thunder Thighs | Stud Finder | ||
The Guardian | 30 | 3 Red Hearts, Blindfolded | Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny | Blank Rune |
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