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Binding of Isaac Wiki

Empty Hearts Challenges

Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.

https://bindingofisaacwiki.com/i/q/bindingofisaacwiki__challenges?b=&c=&e=&i=&h=&d=&_n=200
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
Have a Heart 25
Isaac
 1 Red Heart, 11 Empty Hearts Charm of the Vampire
It LivesMom's Heart
 2 new pills