Have a Heart - Challenge Conditions, Goal, & Unlocks | Binding of Isaac Wiki

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Binding of Isaac Challenge: Have a Heart

Challenges

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Order	25
Featured	Isaac
Hearts (with Amounts)	1 Red Heart, 11 Empty Hearts
Hearts	Red Heart Empty Hearts
Conditions	Charm of the Vampire
Treasure Room	Yes
Shop	Yes
Goal	Mom's Heart It Lives
Unlocked By	Added in Afterbirth: Have a Heart Defeat Mom for the 1st time
Unlocks	2 new pills
DLC Required	Afterbirth

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Order: 24
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Money = Power, Sack of Pennies, 50 coins
Goal:
Isaac
Unlocks: 2 new pills

Order: 28
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: 3 Dollar Bill, Rainbow Baby, Rainbow Worm
Goal:
Mom's Heart It Lives
Unlocks: D8

Order: 22
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions:
Goal:
Mom's Heart It Lives
Unlocks: Get out of Jail Free Card

Order: 21
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions:
Goal:
Mom's Heart It Lives
Unlocks: Gold Heart

Order: 23
Featured:
???
Hearts (with Amounts): 3 Soul Hearts, Blindfolded
Conditions: Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega
Goal:
Satan
Unlocks: Gold Bomb

Order: 26
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield
Goal:
Mega Satan
Unlocks: Poker Chip

Order: 30
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts, Blindfolded
Conditions: Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny
Goal:
Mom's Heart It Lives
Unlocks: Blank Rune

Order: 27
Featured:
???
Hearts (with Amounts): 3 Soul Hearts, Blindfolded
Conditions: 3 Bob's Brain, Thunder Thighs
Goal:
???
Unlocks: Stud Finder

Order: 29
Featured:
Judas
Hearts (with Amounts): 1 Red Heart
Conditions: The Book of Belial, Chocolate Milk
Goal:
Isaac
Unlocks: Kidney Stone

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