Head Trauma - Challenge Conditions, Goal, & Unlocks | Binding of Isaac Wiki

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Binding of Isaac Challenge: Head Trauma

Challenges

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Order	3
Featured	Isaac
Hearts (with Amounts)	3 Red Hearts
Hearts	Red Hearts
Conditions	Tiny Planet, Soy Milk, The Small Rock, Iron Bar
Treasure Room	No
Shop	Yes
Goal	Mom
Unlocked By	Default
Unlocks	Rune of Ehwaz
DLC Required	None

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Order: 2
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Number One, E Coli, Butt Bombs, Flush!, Petrified Poop
Goal:
Mom
Unlocks: Rune of Jera

Order: 13
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts, Blindfolded
Conditions: 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro
Goal:
Mom
Unlocks: Burnt Penny

Order: 20
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions:
Goal:
Mom's Heart It Lives
Unlocks: Rune of Berkano

Order: 19
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts, Blindfolded
Conditions: BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy
Goal:
Isaac
Unlocks: Epic Fetus

Order: 4
Featured:
Eve
Hearts (with Amounts): 2 Red Hearts
Conditions: Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter
Goal:
Satan
Unlocks: Rune of Dagaz

Order: 15
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Cupid's Arrow, My Reflection, Polyphemus
Goal:
Mom
Unlocks: Swallowed Penny

Order: 9
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Dr. Fetus, Remote Detonator, Match Stick
Goal:
Mom's Heart It Lives
Unlocks: Chaos Card

Order: 17
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Anti-Gravity, Strange Attractor, The Mulligan, Spider Baby, Tick
Goal:
Mom
Unlocks: Death's Touch

Order: 12
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: 9 Volt, Habit, Lemon Mishap, 1 Lemon Party pill
Goal:
Mom
Unlocks: Card Against Humanity

When Life Gives You Lemons

Order: 14
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: 9 Volt, The Battery, Deck of Cards, Starter Deck, 2 random tarot cards
Goal:
Mom
Unlocks: SMB Super Fan

It's in the Cards

Order: 11
Featured:
Judas
Hearts (with Amounts): 1 Red Heart
Conditions: Epic Fetus, Loki's Horns
Goal:
Satan
Unlocks: Rules Card

Order: 6
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts, Blindfolded
Conditions: Distant Admiration, Forever Alone, Halo of Flies, Transcendence
Goal:
Mom's Heart It Lives
Unlocks: Rune of Perthro

Order: 7
Featured:
Lazarus
Hearts (with Amounts): 3 Red Hearts
Conditions: Ipecac, Mr. Mega, My Reflection, 1 random Pill
Goal:
Isaac
Unlocks: Suicide King

Order: 5
Featured:
Magdalene
Hearts (with Amounts): 4 Red Hearts
Conditions: Infamy, Bucket of Lard, Thunder Thighs, Yum Heart
Goal:
Mom
Unlocks: Rune of Ansuz

Order: 18
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions:
Goal:
Mom
Unlocks: Technology .5

Order: 16
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Spoon Bender, Technology, Technology 2
Goal:
Mom
Unlocks: Robo-Baby 2.0

Order: 10
Featured:
Magdalene
Hearts (with Amounts): 4 Red Hearts
Conditions: Blue Map, The Compass, Raw Liver, Treasure Map, Yum Heart , Child's Heart, Curse of the Cursed
Goal:
Mom
Unlocks: Credit Card

Order: 8
Featured:
Isaac
Hearts (with Amounts): 3 Soul Hearts, 3 Black Hearts, Blindfolded
Conditions: Guppy's Hair Ball, Guppy's Head, Guppy's Tail
Goal:
Mom
Unlocks: Rune of Algiz

Cat Got Your Tongue

Order: 1
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Curse of Darkness, Curse of the Unknown
Goal:
Mom
Unlocks: Rune of Hagalaz

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