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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Suicide King | 7 | 3 Red Hearts | Ipecac, Mr. Mega, My Reflection, 1 random Pill | Suicide King | ||
The Family Man | 19 | 3 Red Hearts, Blindfolded | BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy | Epic Fetus | ||
PAY TO PLAY | 24 | 3 Red Hearts | Money = Power, Sack of Pennies, 50 coins | 2 new pills | ||
Onan's Streak | 29 | 1 Red Heart | The Book of Belial, Chocolate Milk | Kidney Stone | ||
Pokey Mans | 33 | 3 Red Hearts | Friendly Ball, Mom's Eyeshadow | Charged Key |
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