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Isaac Challenges

Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.

https://bindingofisaacwiki.com/i/q/bindingofisaacwiki__challenges?b=&c=&e=&i=&h=&d=Isaac&_n=200
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
Suicide King 7
Lazarus
 3 Red Hearts Ipecac, Mr. Mega, My Reflection, 1 random Pill
Isaac
 Suicide King
The Family Man 19
Isaac
 3 Red Hearts, Blindfolded BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy
Isaac
 Epic Fetus
PAY TO PLAY 24
Isaac
 3 Red Hearts Money = Power, Sack of Pennies, 50 coins
Isaac
 2 new pills
Onan's Streak 29
Judas
 1 Red Heart The Book of Belial, Chocolate Milk
Isaac
 Kidney Stone
Pokey Mans 33
Isaac
 3 Red Hearts Friendly Ball, Mom's Eyeshadow
Isaac
 Charged Key