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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Solar System | 6 | 3 Red Hearts, Blindfolded | Distant Admiration, Forever Alone, Halo of Flies, Transcendence | Rune of Perthro | ||
Demo Man | 9 | 3 Red Hearts | Dr. Fetus, Remote Detonator, Match Stick | Chaos Card | ||
Purist | 20 | 3 Red Hearts | Rune of Berkano | |||
XXXXXXXXL | 21 | 3 Red Hearts | Gold Heart | |||
SPEED! | 22 | 3 Red Hearts | Get out of Jail Free Card | |||
Have a Heart | 25 | 1 Red Heart, 11 Empty Hearts | Charm of the Vampire | 2 new pills | ||
PRIDE DAY! | 28 | 3 Red Hearts | 3 Dollar Bill, Rainbow Baby, Rainbow Worm | D8 | ||
The Guardian | 30 | 3 Red Hearts, Blindfolded | Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny | Blank Rune | ||
Aprils Fool | 32 | 3 Red Hearts | Maggy Now Holds a Pill! |
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