Cookies on this website are used to improve your experience and display advertising. You agree to the use of cookies by continuing to use this website. Our Privacy Policy contains more information about how we use cookies.
Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
| Solar System | 6 | 3 Red Hearts, Blindfolded | Distant Admiration, Forever Alone, Halo of Flies, Transcendence | Rune of Perthro | ||
| Demo Man | 9 | 3 Red Hearts | Dr. Fetus, Remote Detonator, Match Stick | Chaos Card | ||
| Purist | 20 | 3 Red Hearts | Rune of Berkano | |||
| XXXXXXXXL | 21 | 3 Red Hearts | Gold Heart | |||
| SPEED! | 22 | 3 Red Hearts | Get out of Jail Free Card | |||
| Have a Heart | 25 | 1 Red Heart, 11 Empty Hearts | Charm of the Vampire | 2 new pills | ||
| PRIDE DAY! | 28 | 3 Red Hearts | 3 Dollar Bill, Rainbow Baby, Rainbow Worm | D8 | ||
| The Guardian | 30 | 3 Red Hearts, Blindfolded | Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny | Blank Rune | ||
| Aprils Fool | 32 | 3 Red Hearts | Maggy Now Holds a Pill! |
Cookies on this website are used to improve your experience and display advertising. You agree to the use of cookies by continuing to use this website. Our Privacy Policy contains more information about how we use cookies.