It's in the Cards - Challenge Conditions, Goal, & Unlocks | Binding of Isaac Wiki

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Binding of Isaac Challenge: It's in the Cards

Challenges

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Order	14
Featured	Isaac
Hearts (with Amounts)	3 Red Hearts
Hearts	Red Hearts
Conditions	9 Volt, The Battery, Deck of Cards, Starter Deck, 2 random tarot cards
Treasure Room	No
Shop	Yes
Goal	Mom
Unlocked By	Default
Unlocks	SMB Super Fan
DLC Required	None

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Order: 10
Featured:
Magdalene
Hearts (with Amounts): 4 Red Hearts
Conditions: Blue Map, The Compass, Raw Liver, Treasure Map, Yum Heart , Child's Heart, Curse of the Cursed
Goal:
Mom
Unlocks: Credit Card

Order: 2
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Number One, E Coli, Butt Bombs, Flush!, Petrified Poop
Goal:
Mom
Unlocks: Rune of Jera

Order: 16
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Spoon Bender, Technology, Technology 2
Goal:
Mom
Unlocks: Robo-Baby 2.0

Order: 20
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions:
Goal:
Mom's Heart It Lives
Unlocks: Rune of Berkano

Order: 13
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts, Blindfolded
Conditions: 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro
Goal:
Mom
Unlocks: Burnt Penny

Order: 3
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Tiny Planet, Soy Milk, The Small Rock, Iron Bar
Goal:
Mom
Unlocks: Rune of Ehwaz

Order: 1
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Curse of Darkness, Curse of the Unknown
Goal:
Mom
Unlocks: Rune of Hagalaz

Order: 19
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts, Blindfolded
Conditions: BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy
Goal:
Isaac
Unlocks: Epic Fetus

Order: 4
Featured:
Eve
Hearts (with Amounts): 2 Red Hearts
Conditions: Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter
Goal:
Satan
Unlocks: Rune of Dagaz

Order: 17
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Anti-Gravity, Strange Attractor, The Mulligan, Spider Baby, Tick
Goal:
Mom
Unlocks: Death's Touch

Order: 5
Featured:
Magdalene
Hearts (with Amounts): 4 Red Hearts
Conditions: Infamy, Bucket of Lard, Thunder Thighs, Yum Heart
Goal:
Mom
Unlocks: Rune of Ansuz

Order: 15
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Cupid's Arrow, My Reflection, Polyphemus
Goal:
Mom
Unlocks: Swallowed Penny

Order: 12
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: 9 Volt, Habit, Lemon Mishap, 1 Lemon Party pill
Goal:
Mom
Unlocks: Card Against Humanity

When Life Gives You Lemons

Order: 8
Featured:
Isaac
Hearts (with Amounts): 3 Soul Hearts, 3 Black Hearts, Blindfolded
Conditions: Guppy's Hair Ball, Guppy's Head, Guppy's Tail
Goal:
Mom
Unlocks: Rune of Algiz

Cat Got Your Tongue

Order: 11
Featured:
Judas
Hearts (with Amounts): 1 Red Heart
Conditions: Epic Fetus, Loki's Horns
Goal:
Satan
Unlocks: Rules Card

Order: 9
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Dr. Fetus, Remote Detonator, Match Stick
Goal:
Mom's Heart It Lives
Unlocks: Chaos Card

Order: 18
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions:
Goal:
Mom
Unlocks: Technology .5

Order: 7
Featured:
Lazarus
Hearts (with Amounts): 3 Red Hearts
Conditions: Ipecac, Mr. Mega, My Reflection, 1 random Pill
Goal:
Isaac
Unlocks: Suicide King

Order: 6
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts, Blindfolded
Conditions: Distant Admiration, Forever Alone, Halo of Flies, Transcendence
Goal:
Mom's Heart It Lives
Unlocks: Rune of Perthro

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