Binding of Isaac Wiki
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Mom's Heart Challenges

Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Hearts (with Amounts)
Solar System 6 3 Red Hearts, Blindfolded Distant Admiration, Forever Alone, Halo of Flies, Transcendence Rune of Perthro
Demo Man 9 3 Red Hearts Dr. Fetus, Remote Detonator, Match Stick Chaos Card
Purist 20 3 Red Hearts Rune of Berkano
XXXXXXXXL 21 3 Red Hearts Gold Heart
SPEED! 22 3 Red Hearts Get out of Jail Free Card
Have a Heart 25 1 Red Heart, 11 Empty Hearts Charm of the Vampire 2 new pills
PRIDE DAY! 28 3 Red Hearts 3 Dollar Bill, Rainbow Baby, Rainbow Worm D8
The Guardian 30 3 Red Hearts, Blindfolded Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny Blank Rune
Aprils Fool 32 3 Red Hearts Maggy Now Holds a Pill!