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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.

https://bindingofisaacwiki.com/i/q/bindingofisaacwiki__challenges?b=&c=&e=&i=&h=No&d=&_n=200
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
Pitch Black 1
Isaac
 3 Red Hearts Curse of Darkness, Curse of the Unknown
Mom
 Rune of Hagalaz