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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.

https://bindingofisaacwiki.com/i/q/bindingofisaacwiki__challenges?b=&c=&e=&i=&h=&d=&_n=200
Order
Featured
Hearts (with Amounts)
Conditions
Goal
Unlocks
Pitch Black 1 3 Red Hearts Curse of Darkness, Curse of the Unknown Rune of Hagalaz
High Brow 2 3 Red Hearts Number One, E Coli, Butt Bombs, Flush!, Petrified Poop Rune of Jera
Head Trauma 3 3 Red Hearts Tiny Planet, Soy Milk, The Small Rock, Iron Bar Rune of Ehwaz
Darkness Falls 4 2 Red Hearts Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter Rune of Dagaz
The Tank 5 4 Red Hearts Infamy, Bucket of Lard, Thunder Thighs, Yum Heart Rune of Ansuz
Solar System 6 3 Red Hearts, Blindfolded Distant Admiration, Forever Alone, Halo of Flies, Transcendence Rune of Perthro
Suicide King 7 3 Red Hearts Ipecac, Mr. Mega, My Reflection, 1 random Pill Suicide King
Cat Got Your Tongue 8 3 Soul Hearts, 3 Black Hearts, Blindfolded Guppy's Hair Ball, Guppy's Head, Guppy's Tail Rune of Algiz
Demo Man 9 3 Red Hearts Dr. Fetus, Remote Detonator, Match Stick Chaos Card
Cursed! 10 4 Red Hearts Blue Map, The Compass, Raw Liver, Treasure Map, Yum Heart , Child's Heart, Curse of the Cursed Credit Card
Glass Cannon 11 1 Red Heart Epic Fetus, Loki's Horns Rules Card
When Life Gives You Lemons 12 3 Red Hearts 9 Volt, Habit, Lemon Mishap, 1 Lemon Party pill Card Against Humanity
Beans! 13 3 Red Hearts, Blindfolded 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro Burnt Penny
It's in the Cards 14 3 Red Hearts 9 Volt, The Battery, Deck of Cards, Starter Deck, 2 random tarot cards SMB Super Fan
Slow Roll 15 3 Red Hearts Cupid's Arrow, My Reflection, Polyphemus Swallowed Penny
Computer Savvy 16 3 Red Hearts Spoon Bender, Technology, Technology 2 Robo-Baby 2.0
Waka Waka 17 3 Red Hearts Anti-Gravity, Strange Attractor, The Mulligan, Spider Baby, Tick Death's Touch
The Host 18 3 Red Hearts Technology .5
The Family Man 19 3 Red Hearts, Blindfolded BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy Epic Fetus
Purist 20 3 Red Hearts Rune of Berkano