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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
| Pitch Black | 1 | 3 Red Hearts | Curse of Darkness, Curse of the Unknown | Rune of Hagalaz | ||
| High Brow | 2 | 3 Red Hearts | Number One, E Coli, Butt Bombs, Flush!, Petrified Poop | Rune of Jera | ||
| Head Trauma | 3 | 3 Red Hearts | Tiny Planet, Soy Milk, The Small Rock, Iron Bar | Rune of Ehwaz | ||
| Darkness Falls | 4 | 2 Red Hearts | Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter | Rune of Dagaz | ||
| The Tank | 5 | 4 Red Hearts | Infamy, Bucket of Lard, Thunder Thighs, Yum Heart | Rune of Ansuz | ||
| Solar System | 6 | 3 Red Hearts, Blindfolded | Distant Admiration, Forever Alone, Halo of Flies, Transcendence | Rune of Perthro | ||
| Suicide King | 7 | 3 Red Hearts | Ipecac, Mr. Mega, My Reflection, 1 random Pill | Suicide King | ||
| Cat Got Your Tongue | 8 | 3 Soul Hearts, 3 Black Hearts, Blindfolded | Guppy's Hair Ball, Guppy's Head, Guppy's Tail | Rune of Algiz | ||
| Demo Man | 9 | 3 Red Hearts | Dr. Fetus, Remote Detonator, Match Stick | Chaos Card | ||
| Cursed! | 10 | 4 Red Hearts | Blue Map, The Compass, Raw Liver, Treasure Map, Yum Heart , Child's Heart, Curse of the Cursed | Credit Card | ||
| Glass Cannon | 11 | 1 Red Heart | Epic Fetus, Loki's Horns | Rules Card | ||
| When Life Gives You Lemons | 12 | 3 Red Hearts | 9 Volt, Habit, Lemon Mishap, 1 Lemon Party pill | Card Against Humanity | ||
| Beans! | 13 | 3 Red Hearts, Blindfolded | 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro | Burnt Penny | ||
| It's in the Cards | 14 | 3 Red Hearts | 9 Volt, The Battery, Deck of Cards, Starter Deck, 2 random tarot cards | SMB Super Fan | ||
| Slow Roll | 15 | 3 Red Hearts | Cupid's Arrow, My Reflection, Polyphemus | Swallowed Penny | ||
| Computer Savvy | 16 | 3 Red Hearts | Spoon Bender, Technology, Technology 2 | Robo-Baby 2.0 | ||
| Waka Waka | 17 | 3 Red Hearts | Anti-Gravity, Strange Attractor, The Mulligan, Spider Baby, Tick | Death's Touch | ||
| The Host | 18 | 3 Red Hearts | Technology .5 | |||
| The Family Man | 19 | 3 Red Hearts, Blindfolded | BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy | Epic Fetus | ||
| Purist | 20 | 3 Red Hearts | Rune of Berkano |
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