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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
| Pitch Black | 1 | 3 Red Hearts | Curse of Darkness, Curse of the Unknown | Rune of Hagalaz | ||
| High Brow | 2 | 3 Red Hearts | Number One, E Coli, Butt Bombs, Flush!, Petrified Poop | Rune of Jera | ||
| Head Trauma | 3 | 3 Red Hearts | Tiny Planet, Soy Milk, The Small Rock, Iron Bar | Rune of Ehwaz | ||
| Darkness Falls | 4 | 2 Red Hearts | Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter | Rune of Dagaz | ||
| The Tank | 5 | 4 Red Hearts | Infamy, Bucket of Lard, Thunder Thighs, Yum Heart | Rune of Ansuz | ||
| Solar System | 6 | 3 Red Hearts, Blindfolded | Distant Admiration, Forever Alone, Halo of Flies, Transcendence | Rune of Perthro | ||
| Suicide King | 7 | 3 Red Hearts | Ipecac, Mr. Mega, My Reflection, 1 random Pill | Suicide King | ||
| Demo Man | 9 | 3 Red Hearts | Dr. Fetus, Remote Detonator, Match Stick | Chaos Card | ||
| Cursed! | 10 | 4 Red Hearts | Blue Map, The Compass, Raw Liver, Treasure Map, Yum Heart , Child's Heart, Curse of the Cursed | Credit Card | ||
| When Life Gives You Lemons | 12 | 3 Red Hearts | 9 Volt, Habit, Lemon Mishap, 1 Lemon Party pill | Card Against Humanity | ||
| Beans! | 13 | 3 Red Hearts, Blindfolded | 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro | Burnt Penny | ||
| It's in the Cards | 14 | 3 Red Hearts | 9 Volt, The Battery, Deck of Cards, Starter Deck, 2 random tarot cards | SMB Super Fan | ||
| Slow Roll | 15 | 3 Red Hearts | Cupid's Arrow, My Reflection, Polyphemus | Swallowed Penny | ||
| Computer Savvy | 16 | 3 Red Hearts | Spoon Bender, Technology, Technology 2 | Robo-Baby 2.0 | ||
| Waka Waka | 17 | 3 Red Hearts | Anti-Gravity, Strange Attractor, The Mulligan, Spider Baby, Tick | Death's Touch | ||
| The Host | 18 | 3 Red Hearts | Technology .5 | |||
| The Family Man | 19 | 3 Red Hearts, Blindfolded | BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy | Epic Fetus | ||
| Purist | 20 | 3 Red Hearts | Rune of Berkano | |||
| XXXXXXXXL | 21 | 3 Red Hearts | Gold Heart | |||
| SPEED! | 22 | 3 Red Hearts | Get out of Jail Free Card | |||
| PAY TO PLAY | 24 | 3 Red Hearts | Money = Power, Sack of Pennies, 50 coins | 2 new pills | ||
| I RULE! | 26 | 3 Red Hearts | The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield | Poker Chip | ||
| PRIDE DAY! | 28 | 3 Red Hearts | 3 Dollar Bill, Rainbow Baby, Rainbow Worm | D8 | ||
| The Guardian | 30 | 3 Red Hearts, Blindfolded | Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny | Blank Rune | ||
| Backasswards | 31 | 3 Red Hearts | 8-10 random items | Laz Bleeds More! | ||
| Aprils Fool | 32 | 3 Red Hearts | Maggy Now Holds a Pill! | |||
| Pokey Mans | 33 | 3 Red Hearts | Friendly Ball, Mom's Eyeshadow | Charged Key | ||
| Ultra Hard | 34 | 3 Red Hearts | Key Piece 1, Key Piece 2, Curse of the Labyrinth, Curse of the Blind, Curse of the Lost, Curse of the Maze | Samson Feels Healthy! | ||
| Pong | 35 | 3 Red Hearts | Cupid's Arrow, Rubber Cement | Greed's Gullet |
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