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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Pitch Black | 1 | 3 Red Hearts | Curse of Darkness, Curse of the Unknown | Rune of Hagalaz | ||
High Brow | 2 | 3 Red Hearts | Number One, E Coli, Butt Bombs, Flush!, Petrified Poop | Rune of Jera | ||
Head Trauma | 3 | 3 Red Hearts | Tiny Planet, Soy Milk, The Small Rock, Iron Bar | Rune of Ehwaz | ||
Darkness Falls | 4 | 2 Red Hearts | Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter | Rune of Dagaz | ||
The Tank | 5 | 4 Red Hearts | Infamy, Bucket of Lard, Thunder Thighs, Yum Heart | Rune of Ansuz | ||
Solar System | 6 | 3 Red Hearts, Blindfolded | Distant Admiration, Forever Alone, Halo of Flies, Transcendence | Rune of Perthro | ||
Suicide King | 7 | 3 Red Hearts | Ipecac, Mr. Mega, My Reflection, 1 random Pill | Suicide King | ||
Demo Man | 9 | 3 Red Hearts | Dr. Fetus, Remote Detonator, Match Stick | Chaos Card | ||
Cursed! | 10 | 4 Red Hearts | Blue Map, The Compass, Raw Liver, Treasure Map, Yum Heart , Child's Heart, Curse of the Cursed | Credit Card | ||
When Life Gives You Lemons | 12 | 3 Red Hearts | 9 Volt, Habit, Lemon Mishap, 1 Lemon Party pill | Card Against Humanity | ||
Beans! | 13 | 3 Red Hearts, Blindfolded | 9 Volt, The Bean, The Black Bean, Butt Bomb, Pyro | Burnt Penny | ||
It's in the Cards | 14 | 3 Red Hearts | 9 Volt, The Battery, Deck of Cards, Starter Deck, 2 random tarot cards | SMB Super Fan | ||
Slow Roll | 15 | 3 Red Hearts | Cupid's Arrow, My Reflection, Polyphemus | Swallowed Penny | ||
Computer Savvy | 16 | 3 Red Hearts | Spoon Bender, Technology, Technology 2 | Robo-Baby 2.0 | ||
Waka Waka | 17 | 3 Red Hearts | Anti-Gravity, Strange Attractor, The Mulligan, Spider Baby, Tick | Death's Touch | ||
The Host | 18 | 3 Red Hearts | Technology .5 | |||
The Family Man | 19 | 3 Red Hearts, Blindfolded | BFFS!, Brother Bobby, Dad's Key, Rotten Baby, Sister Maggy | Epic Fetus | ||
Purist | 20 | 3 Red Hearts | Rune of Berkano | |||
XXXXXXXXL | 21 | 3 Red Hearts | Gold Heart | |||
SPEED! | 22 | 3 Red Hearts | Get out of Jail Free Card | |||
PAY TO PLAY | 24 | 3 Red Hearts | Money = Power, Sack of Pennies, 50 coins | 2 new pills | ||
I RULE! | 26 | 3 Red Hearts | The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield | Poker Chip | ||
PRIDE DAY! | 28 | 3 Red Hearts | 3 Dollar Bill, Rainbow Baby, Rainbow Worm | D8 | ||
The Guardian | 30 | 3 Red Hearts, Blindfolded | Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny | Blank Rune | ||
Backasswards | 31 | 3 Red Hearts | 8-10 random items | Laz Bleeds More! | ||
Aprils Fool | 32 | 3 Red Hearts | Maggy Now Holds a Pill! | |||
Pokey Mans | 33 | 3 Red Hearts | Friendly Ball, Mom's Eyeshadow | Charged Key | ||
Ultra Hard | 34 | 3 Red Hearts | Key Piece 1, Key Piece 2, Curse of the Labyrinth, Curse of the Blind, Curse of the Lost, Curse of the Maze | Samson Feels Healthy! | ||
Pong | 35 | 3 Red Hearts | Cupid's Arrow, Rubber Cement | Greed's Gullet |
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