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Welcome to The Binding of Isaac challenge guide. Click on a challenge to learn more.
Darkness Falls | 4 | 2 Red Hearts | Pentagram, Dead Bird, Whore of Babylon, Razor Blade, Sacrificial Dagger, Dark Matter | Rune of Dagaz | ||
Glass Cannon | 11 | 1 Red Heart | Epic Fetus, Loki's Horns | Rules Card | ||
Blue Bomber | 23 | 3 Soul Hearts, Blindfolded | Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega | Gold Bomb | ||
I RULE! | 26 | 3 Red Hearts | The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield | Poker Chip | ||
Ultra Hard | 34 | 3 Red Hearts | Key Piece 1, Key Piece 2, Curse of the Labyrinth, Curse of the Blind, Curse of the Lost, Curse of the Maze | Samson Feels Healthy! |
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