The Guardian - Challenge Conditions, Goal, & Unlocks

Binding of Isaac Wiki

Binding of Isaac Challenge: The Guardian

Challenges

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Order	30
Featured	Isaac
Hearts (with Amounts)	3 Red Hearts, Blindfolded
Hearts	Blindfolded Red Hearts
Conditions	Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny
Treasure Room	No
Shop	Yes
Goal	It Lives Mom's Heart
Unlocked By	Added in Afterbirth: The Guardian Defeat Mom for the 1st time
Unlocks	Blank Rune
DLC Required	Afterbirth

Order: 23
Featured:
???
Hearts (with Amounts): 3 Soul Hearts, Blindfolded
Conditions: Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega
Goal:
Satan
Unlocks: Gold Bomb

Blue Bomber

Order: 24
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Money = Power, Sack of Pennies, 50 coins
Goal:
Isaac
Unlocks: 2 new pills

PAY TO PLAY

Order: 25
Featured:
Isaac
Hearts (with Amounts): 1 Red Heart, 11 Empty Hearts
Conditions: Charm of the Vampire
Goal:
It Lives Mom's Heart
Unlocks: 2 new pills

Have a Heart

Order: 26
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield
Goal:
Mega Satan
Unlocks: Poker Chip