The Guardian - Challenge Conditions, Goal, & Unlocks | Binding of Isaac Wiki

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Binding of Isaac Challenge: The Guardian

Challenges

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Order	30
Featured	Isaac
Hearts (with Amounts)	3 Red Hearts, Blindfolded
Hearts	Red Hearts Blindfolded
Conditions	Holy Grail, Isaac's Heart, Punching Bag, Spear of Destiny
Treasure Room	No
Shop	Yes
Goal	Mom's Heart It Lives
Unlocked By	Added in Afterbirth: The Guardian Defeat Mom for the 1st time
Unlocks	Blank Rune
DLC Required	Afterbirth

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Order: 24
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: Money = Power, Sack of Pennies, 50 coins
Goal:
Isaac
Unlocks: 2 new pills

Order: 21
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions:
Goal:
Mom's Heart It Lives
Unlocks: Gold Heart

Order: 27
Featured:
???
Hearts (with Amounts): 3 Soul Hearts, Blindfolded
Conditions: 3 Bob's Brain, Thunder Thighs
Goal:
???
Unlocks: Stud Finder

Order: 26
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: The Boomerang, Key Piece 1, Key Piece 2, The Ladder, Mom's Knife, Trinity Shield
Goal:
Mega Satan
Unlocks: Poker Chip

Order: 25
Featured:
Isaac
Hearts (with Amounts): 1 Red Heart, 11 Empty Hearts
Conditions: Charm of the Vampire
Goal:
Mom's Heart It Lives
Unlocks: 2 new pills

Order: 28
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions: 3 Dollar Bill, Rainbow Baby, Rainbow Worm
Goal:
Mom's Heart It Lives
Unlocks: D8

Order: 22
Featured:
Isaac
Hearts (with Amounts): 3 Red Hearts
Conditions:
Goal:
Mom's Heart It Lives
Unlocks: Get out of Jail Free Card

Order: 29
Featured:
Judas
Hearts (with Amounts): 1 Red Heart
Conditions: The Book of Belial, Chocolate Milk
Goal:
Isaac
Unlocks: Kidney Stone

Order: 23
Featured:
???
Hearts (with Amounts): 3 Soul Hearts, Blindfolded
Conditions: Brother Bobby, Kamikaze!, Pyromaniac, Mr. Mega
Goal:
Satan
Unlocks: Gold Bomb

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