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Welcome to The Binding of Isaac item guide. Click on an item to learn more.
| Mine Crafter | 427 | Mine Crafter | When used, places an explosive TNT barrel that can be pushed and used to destroy rocks or damage enemies. If used a second time in the same room while the previous TNT barrel is still intact, it will remotely explode the TNT. |
| Tear Detonator | 383 | Tear Detonator | When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head. |
| Wooden Nickel | 349 | Wooden Nickel | When used, has a 50% chance to drop one random type of coin (penny, nickel, or dime). |
| D10 | 285 | D10 | Rerolls the enemies in a room. Only rerolls enemies that are still alive (does not spawn new enemies). |
| Guppy's Head | 145 | Guppy's Head | Spawns 2-4 blue flies to damage enemies. |
| Tammy's Head | 38 | Tammy's Head | Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears. |
| The Bean | 111 | The Bean | Isaac releases bad gas, poisoning any enemy in close vicinity. |
| The Poop | 36 | The Poop | Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop. |
| Unicorn Stump | 298 | Unicorn Stump | Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears. |
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