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Welcome to The Binding of Isaac item guide. Click on an item to learn more.
Guppy's Head | 145 | Guppy's Head | Spawns 2-4 blue flies to damage enemies. |
Guppy's Paw | 133 | Guppy's Paw | Removes one red heart container in exchange for gaining 3 Soul Hearts. |
Head of Krampus | 293 | Head of Krampus | Fires a cross-patterned brimstone shot, just like The Fallen and Krampus shoot. |
How to Jump | 282 | How to Jump | Gives Isaac the ability to jump (over gaps, spikes, etc.). |
Isaac's Tears | 323 | Isaac's Tears | Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one. |
IV Bag | 135 | IV Bag | Upon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine. |
Kamikaze! | 40 | Kamikaze! | Creates an explosion in the same area as Isaac, dealing half a heart of damage to him and also damaging all enemies caught in the blast radius. |
Lemon Mishap | 56 | Lemon Mishap | Creates a small yellow pool of creep, which damages enemies that cross it. |
Magic Fingers | 295 | Magic Fingers | For 1 coin, damages all enemies in the room. |
Mom's Bottle of Pills | 102 | Mom's Bottle of Pills | Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough. |
Mom's Bra | 39 | Mom's Bra | Upon use, petrifies all enemies in the current room for approximately 4 seconds. |
Mom's Pad | 41 | Mom's Pad | Upon use, inflicts fear to all enemies in the room for 5 seconds. |
Monster Manual | 123 | Monster Manual | Summons a random familiar for the current room. Can summon familiars not yet unlocked. |
Monstro's Tooth | 86 | Monstro's Tooth | Monstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies. |
Mr. Boom | 37 | Mr. Boom | Drops a large bomb. |
My Little Unicorn | 77 | My Little Unicorn | Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies. |
Notched Axe | 147 | Notched Axe | Isaac holds the axe above his head for as long as the spacebar button is held (or until he leaves the room). While holding the axe, Isaac can break any rock he touches, but cannot attack or pick up other items. |
Pandora's Box | 297 | Pandora's Box | Upon use, spawns certain pickups or itemsdepending on the floor it is used on. Single-use. |
Portable Slot | 177 | Portable Slot | Upon activation, 1 coin will be consumed, and a random pickup may drop, similar to the slot machine. |
Prayer Card | 146 | Prayer Card | Grants an eternal heart per use. |
Razor Blade | 126 | Razor Blade | Upon use, deals one heart of damage to Isaac and grants +1.2 damage for the current room. |
Red Candle | 289 | Red Candle | Throws a persistent flame that deals high damage and diminishes as it damages enemies or blocks shots. |
Remote Detonator | 137 | Remote Detonator | Bombs you place explode only when you use this item. Gives 5 bombs. |
Satanic Bible | 292 | Satanic Bible | Upon activation, Isaac gains a black heart. |
Scissors | 325 | Scissors | Upon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage. |
Shoop Da Whoop! | 49 | Shoop Da Whoop! | Fires a laser from Isaac's mouth. |
Spider Butt | 171 | Spider Butt | Damages all enemies in the room and slows them and their projectiles down. |
Tammy's Head | 38 | Tammy's Head | Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears. |
Telepathy for Dummies | 192 | Telepathy for Dummies | Upon activation, grants homing tears for the current room. |
Teleport | 44 | Teleport | Teleports you to a random room on the level. |
The Bean | 111 | The Bean | Isaac releases bad gas, poisoning any enemy in close vicinity. |
The Bible | 33 | The Bible | Upon activation, Isaac gains flight, allowing him to pass over all obstacles in the current room. Instantly kills Mom, Mom's Heart, and It Lives when activated, but will kill Isaac when activated while fighting Satan. |
The Book of Belial | 34 | The Book of Belial | Upon use increases damage by 2 for the current room and by a further +50% if the character also has the Blood of the Martyr. |
The Book of Sin | 97 | The Book of Sin | Spawns a random pickup, pill, card, or trinket. |
The Boomerang | 338 | The Boomerang | Throws a short-range boomerang which does a bit of damage and has a high chance to stun the enemy for 2 seconds. Can also be used to grab pickups. |
The Candle | 164 | The Candle | Throws out a blue flame that can pass over gaps (but not through rocks). The flame damages anything in its path. |
The D6 | 105 | The D6 | Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool. |
The Gamekid | 93 | The Gamekid | Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed. |
The Hourglass | 66 | The Hourglass | Upon activation, enemies and their projectiles are slowed down for a short duration. |
The Jar | 290 | The Jar | When at full health, up to 4 extra hearts can be stored in the jar. |
The Nail | 83 | The Nail | Adds one soul heart and allows the breaking of rocksand damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room. |
The Necronomicon | 35 | The Necronomicon | Damages all enemies in the room significantly. |
The Pinking Shears | 107 | The Pinking Shears | Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage. |
The Poop | 36 | The Poop | Spawns a pile of poop where the character is standing and knocks nearby monsters back. May yield pickups like regular poop. |
Undefined | 324 | Undefined | Teleports Isaac to either the Secret Room, Super Secret Room, Treasure Room, or I AM ERROR. |
Unicorn Stump | 298 | Unicorn Stump | Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears. |
We Need to Go Deeper! | 84 | We Need to Go Deeper! | Creates a trapdoor to go to the next floor. If used in The Womb, it will create a trapdoor to Sheol, even if the player hasn't unlocked it. |
White Pony | 181 | White Pony | Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky. |
Yum Heart | 45 | Yum Heart | Restores 1 whole red heart. |
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