Binding of Isaac Wiki
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Afterbirth+ Items

Welcome to The Binding of Isaac item guide. Click on an item to learn more.
Item ID
Contagion 466 Contagion The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.
Dad's Lost Coin 455 Dad's Lost Coin Increases range by 1.5. Drops a lucky penny.
Dad's Ring 546 Dad's Ring Creates a ring of light around Isaac that petrifies enemies in contact.
Dark Prince's Crown 442 Dark Prince's Crown Increases range, tears, and shot speed when at exactly one red heart.
Dead Tooth 446 Dead Tooth While firing, Isaac gains a green aura that poisons nearby enemies.
Death's List 530 Death's List Grants a reward if all enemies in a room are killed in the order they are marked.
Depression 469 Depression Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Divorce Papers 547 Divorce Papers Spawns a Mysterious Paper, increases tears, and grants a bone heart.
Dog Tooth 445 Dog Tooth Increases damage and speed. Upon entering a room adjacent to a secret room, a howl sound effect will play.
Duality 498 Duality Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Eucharist 499 Eucharist An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Euthanasia 496 Euthanasia Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.
Eye of Belial 462 Eye of Belial Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Eye of Greed 450 Eye of Greed Adds a chance to fire tears that temporarily stun enemies and turn them into gold. Any enemy killed while in this state will drop coins.
Fast Bombs 517 Fast Bombs Grants 7 bombs and allows bombs to be placed rapidly.
Finger! 467 Finger! Spawns a finger familiar that points at enemies, dealing constant damage.
Ghost Pepper 495 Ghost Pepper Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
Glaucoma 460 Glaucoma Adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Glyph of Balance 464 Glyph of Balance Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.
Hushy 470 Hushy Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
King Baby 472 King Baby Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.
Leprosy 525 Leprosy Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Lil Spewer 537 Lil Spewer Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Linger Bean 447 Linger Bean Adds a chance to fire a gas cloud that damages nearby enemies.
Little Horn 503 Little Horn Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Marbles 538 Marbles Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
Marrow 541 Marrow Grants one bone heart and spawns three red heart pickups.
Metal Plate 449 Metal Plate Adds a chance to reflect enemy shots. Grants one soul heart.
Moldy Bread 456 Moldy Bread Grants one full red heart container.
Mom's Razor 508 Mom's Razor Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Mystery Egg 539 Mystery Egg Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Parasitoid 461 Parasitoid Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
Pointy Rib 544 Pointy Rib Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Poke Go 505 Poke Go Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.
Polydactyly 454 Polydactyly Allows Isaac to carry two cards, pills, or any combination of both at the same time. Drops a random card or pill.
Pop! 529 Pop! Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
Sack of Sacks 500 Sack of Sacks Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
Schoolbag 534 Schoolbag Allows Isaac to hold two active items.
Shade 468 Shade Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
Shard of Glass 448 Shard of Glass Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Sinus Infection 459 Sinus Infection Adds a chance to fire a booger which sticks to enemies and poisons them.
Slipped Rib 542 Slipped Rib Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Sulfuric Acid 463 Sulfuric Acid Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.
Tarot Cloth 451 Tarot Cloth Drops a random card or rune. Doubles the effects of cards and runes.
Technology Zero 524 Technology Zero Connects Isaac's tears with electricity that can damage enemies.
Tonsil 474 Tonsil Grants a familiar that can block enemy shots.
Trisagion 533 Trisagion Tears are replaced with piercing white blasts of light.
Varicose Veins 452 Varicose Veins Taking damage releases a ring of 10 high damage tears.
YO LISTEN! 492 YO LISTEN! +1 luck. Spawns a fairy familiar that points out secret room entrances and tinted rocks.
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