Item: Champion Belt Share

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Item: 229.0 Monstro's Lung Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.

Item: 156.0 Habit When Isaac is hit, 1 point of an item's charge is filled.

Item: 71.0 Mini Mush Increases Speed and Shot Height and decreases Isaac's size, but lowers Range.

Item: 370.0 Mr. Dolly Tears and Range up. Spawns 3 random types of hearts on the floor when picked up.

Item: 320.0 ???'s Only Friend Summons a big attack fly that can be controlled with the shooting direction-keys.

Item: 531.0 Haemolacria Tears are now fired in an arc. Upon hitting the floor, an obstacle, or an enemy, they burst into many smaller tears in all directions. Increases tear delay.

Item: 114.0 Mom's Knife Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.

Item: 372.0 Charged Baby A familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.

Item: 540.0 Flat Stone Tears bounce off the floor. Tears that hit an enemy after bouncing deal splash damage to all nearby enemies for 25% of Isaac's tear damage.

Item: 50.0 Steven Increases Damage by 1.

Item: 435.0 Lil' Loki A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.

Item: 267.0 Robo-Baby 2.0 Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.

Item: 470.0 Hushy Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.

Item: 535.0 Blanket Grants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.

Item: 223.0 Pyromaniac Isaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.

Item: 430.0 Papa Fly A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.

Item: 520.0 Jumper Cables Grants an active item charge every 15 enemies killed.

Item: 367.0 Sticky Bombs +5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.

Item: 362.0 Lil Chest Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.

Item: 388.0 Key Bum Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.

Item: 542.0 Slipped Rib Spawns a bone familiar that circles around Isaac and reflects enemy shots.

Item: 513.0 Bozo Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.

Item: 106.0 Mr. Mega Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.

Item: 108.0 The Wafer All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.

Item: 21.0 The Compass Reveals all special rooms (except secret rooms of any kind).

Item: 407.0 Purity This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.

Item: 196.0 Squeezy Increases tears by 0.4, and spawns 2 Soul Hearts pickups.

Item: 322.0 Mongo Baby Summons a familiar that copies the tears of Isaac's other familiars.

Item: 234.0 Infestation 2 Spawns allied blue spiders from killed enemies.

Item: 456.0 Moldy Bread Grants one full red heart container.

Achievement: Unlocked a new co-player baby. Defeat Mega Satan as The Forgotten 403

Achievement: Beat depths without taking damage. Beat chapter 3 without taking damage 39

Achievement: Unlocked new bosses! Defeat ??? as 3 different characters 346

Item: 518.0 Buddy in a Box Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.

Achievement: Unlocked a new item. Become Beelzebub 352
PS4 343

Achievement: Unlocked a new item. Open 20 locked chests 371
PS4 362

Achievement: Unlocked a new item. Defeat all 5 Harbingers 372
PS4 363

Achievement: Unlocked a new item. Beat chapter 1 without taking damage 351
PS4 342

Achievement: Unlocked a new item. Participate in 31 Daily Challenges (they don't have to be consecutive; it will still count if you die in the first room) 325

Achievement: Unlocked a new item. Defeat Hush as Magdalene 180

Item: 28.0 The Belt Increases speed by 0.3.

Achievement: Unlocked a new item. (Also unlocks the Ball of Bandages) Defeat Mom for the 1st time 6

Item: 207.0 Ball of Bandages Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.

Item: 136.0 Best Friend Deploys a decoy Isaac that eventually explodes with an increased blast radius.

Item: 274.0 Best Bud When hit, summons a white attack fly similar to Distant Admiration for the current room.

Achievement: Unlocked a new item. Defeat ??? as Lilith 219

Challenge: Isaac Mom 13.0 Isaac 3 Red Hearts, Blindfolded

Item: 412.0 Cambion Conception After taking damage a certain amount of times, a permanent demonic familiar spawns.

Item: 208.0 Champion Belt Increases damage, but also increases the chance of champion enemies appearing.

Achievement: Built him out of meat cubes. Make a Super Meat Boy by picking up 4 Cubes of Meat in one run; see methods to create a Super Meat Boy 144