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Welcome to The Binding of Isaac item guide. Click on an item to learn more.

https://bindingofisaacwiki.com/i/q/bindingofisaacwiki__items?a=&c=&e=&_n=25
Item ID
Icon
Description
Rubber Cement 221 Rubber Cement Tears bounce off walls, enemies, and environmental objects.
Screw 255 Screw +0.5 tears up, +0.2 shot speed up.
Sharp Plug 205 Sharp Plug Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Sissy Longlegs 280 Sissy Longlegs Wanders about the room, occasionally spawning blue spiders.
Sister Maggy 67 Sister Maggy A familiar that follows Isaac around shooting blood tears.
Skatole 9 Skatole All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
Skeleton Key 17 Skeleton Key Sets your key count to the maximum of 99.
Smart Fly 264 Smart Fly After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
SMB Super Fan 189 SMB Super Fan Increases all stats.
Soy Milk 330 Soy Milk Tears shrink and do much less damage, but fire in very rapid succession.
Speed Ball 143 Speed Ball Increases speed by 0.3 and shot speed by 20%.
Spelunker Hat 91 Spelunker Hat Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.
Spider Baby 211 Spider Baby When hit, spawns up to 2 blue spiders.
Spider Bite 89 Spider Bite Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Spirit of the Night 159 Spirit of the Night Grants spectral tears and flight.
Spoon Bender 3 Spoon Bender Grants Isaac homing tears.
Squeezy 196 Squeezy Increases tears by 0.4, and spawns 2 Soul Hearts pickups.
Starter Deck 251 Starter Deck Isaac can hold 2 cards at once and all pills are replaced by cards.
Steam Sale 64 Steam Sale Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Stem Cells 176 Stem Cells Adds one filled heart container and increases Shot Speed.
Steven 50 Steven Increases Damage by 1.
Stigmata 138 Stigmata Increases damage, and adds 1 heart container.
Strange Attractor 315 Strange Attractor Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
The Body 334 The Body Adds 3 heart containers.
The Common Cold 103 The Common Cold Adds a chance to shoot poison tears, dealing damage over time when inflicted.
The Compass 21 The Compass Reveals all special rooms (except secret rooms of any kind).
The Halo 101 The Halo Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
The Inner Eye 2 The Inner Eye Grants triple shot but decreases tears.
The Ladder 60 The Ladder Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
The Ludovico Technique 329 The Ludovico Technique Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
The Mark 79 The Mark Increases Damage and Speed, plus adds one Soul Heart.
The Mind 333 The Mind Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
The Mulligan 151 The Mulligan Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
The Negative 328 The Negative If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room.
The Pact 80 The Pact Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
The Parasite 104 The Parasite Isaac's tears split in two when they hit something.
The Peeper 155 The Peeper Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Fliesdamaging enemies it passes through.
The Polaroid 327 The Polaroid If the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
The Relic 98 The Relic Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
The Sad Onion 1 The Sad Onion Increases Tears by 0.7.
The Small Rock 90 The Small Rock Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
The Soul 335 The Soul Grants two soul hearts. Isaac now repels enemy projectiles.
The Virus 13 The Virus Inflicts poison to enemies who make contact with Isaac. Speed down.
The Wafer 108 The Wafer All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
There's Options 249 There's Options There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.
Thunder Thighs 314 Thunder Thighs Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Tough Love 150 Tough Love Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
Virgo 303 Virgo Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
X-Ray Vision 76 X-Ray Vision Reveals and opens all Secret Room and Super Secret Room entrances.