Item: Obsessed Fan Share

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Item: 373.0 Dead Eye Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.

Item: 138.0 Stigmata Increases damage, and adds 1 heart container.

Item: 444.0 Lead Pencil After every 15 tears fired, Isaac will fire a high-damage cluster of tears.

Item: 520.0 Jumper Cables Grants an active item charge every 15 enemies killed.

Item: 262.0 Missing Page 2 Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.

Item: 310.0 Eve's Mascara Doubles damage, halves tears stat, and greatly reduces shot speed.

Item: 121.0 Odd Mushroom Grants an empty heart container. Increases damage, range and shot height while reducing speed.

Item: 109.0 Money = Power Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.

Item: 517.0 Fast Bombs Grants 7 bombs and allows bombs to be placed rapidly.

Item: 410.0 Evil Eye While firing tears, Isaac has a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac. The eye will be destroyed if it comes into contact with an enemy or obstacle.

Item: 131.0 Bomb Bag Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.

Item: 218.0 Placenta Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.

Item: 261.0 Proptosis Tears start out massive with high damage, and then shrink down and become weaker over a short range.

Item: 27.0 Wooden Spoon Increases speed by 0.3.

Item: 395.0 Tech X Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.

Item: 464.0 Glyph of Balance Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.

Item: 299.0 Taurus Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.

Item: 415.0 Crown of Light Gives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.

Item: 197.0 Jesus Juice Increases Damage and Range.

Item: 79.0 The Mark Increases Damage and Speed, plus adds one Soul Heart.

Item: 54.0 Treasure Map Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.

Item: 231.0 Ball of Tar Adds a chance to shoot slowing tears and the character leaves a trail of slowing creep behind as he moves, impeding enemies' speed.

Item: 76.0 X-Ray Vision Reveals and opens all Secret Room and Super Secret Room entrances.

Item: 95.0 Robo-Baby Follows Isaac around, shooting enemies with an eye laser similar to Technology.

Item: 394.0 Marked Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.

Item: 321.0 Samson's Chains Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.

Item: 266.0 Juicy Sack A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.

Item: 533.0 Trisagion Tears are replaced with piercing white blasts of light.

Item: 167.0 Harlequin Baby Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.

Item: 532.0 Lachryphagy Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.

Item: 426.0 Obsessed Fan A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.

Item: 279.0 Big Fan Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.

Challenge: Isaac Mom 14.0 Isaac 3 Red Hearts

Challenge: Isaac Mom's Heart, It Lives 9.0 Isaac 3 Red Hearts

Challenge: Isaac Isaac 19.0 Isaac 3 Red Hearts, Blindfolded

Challenge: Magdalene Mom 10.0 Magdalene 4 Red Hearts

Item: 382.0 Friendly Ball Throwing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be charmed until it dies, persisting between floors.

Item: 409.0 Empty Vessel While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.

Item: 513.0 Bozo Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.

Item: 189.0 SMB Super Fan Increases all stats.