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Welcome to The Binding of Isaac item guide. Click on an item to learn more.
Rubber Cement | 221 | Rubber Cement | Tears bounce off walls, enemies, and environmental objects. |
Screw | 255 | Screw | +0.5 tears up, +0.2 shot speed up. |
Sharp Plug | 205 | Sharp Plug | Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac. |
Sissy Longlegs | 280 | Sissy Longlegs | Wanders about the room, occasionally spawning blue spiders. |
Sister Maggy | 67 | Sister Maggy | A familiar that follows Isaac around shooting blood tears. |
Skatole | 9 | Skatole | All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage. |
Skeleton Key | 17 | Skeleton Key | Sets your key count to the maximum of 99. |
Smart Fly | 264 | Smart Fly | After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared. |
SMB Super Fan | 189 | SMB Super Fan | Increases all stats. |
Soy Milk | 330 | Soy Milk | Tears shrink and do much less damage, but fire in very rapid succession. |
Speed Ball | 143 | Speed Ball | Increases speed by 0.3 and shot speed by 20%. |
Spelunker Hat | 91 | Spelunker Hat | Reveals type of adjacent rooms, including location for secret rooms and super secret rooms. |
Spider Baby | 211 | Spider Baby | When hit, spawns up to 2 blue spiders. |
Spider Bite | 89 | Spider Bite | Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them. |
Spirit of the Night | 159 | Spirit of the Night | Grants spectral tears and flight. |
Spoon Bender | 3 | Spoon Bender | Grants Isaac homing tears. |
Squeezy | 196 | Squeezy | Increases tears by 0.4, and spawns 2 Soul Hearts pickups. |
Starter Deck | 251 | Starter Deck | Isaac can hold 2 cards at once and all pills are replaced by cards. |
Steam Sale | 64 | Steam Sale | Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup. |
Stem Cells | 176 | Stem Cells | Adds one filled heart container and increases Shot Speed. |
Steven | 50 | Steven | Increases Damage by 1. |
Stigmata | 138 | Stigmata | Increases damage, and adds 1 heart container. |
Strange Attractor | 315 | Strange Attractor | Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears. |
The Body | 334 | The Body | Adds 3 heart containers. |
The Common Cold | 103 | The Common Cold | Adds a chance to shoot poison tears, dealing damage over time when inflicted. |
The Compass | 21 | The Compass | Reveals all special rooms (except secret rooms of any kind). |
The Halo | 101 | The Halo | Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height. |
The Inner Eye | 2 | The Inner Eye | Grants triple shot but decreases tears. |
The Ladder | 60 | The Ladder | Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections. |
The Ludovico Technique | 329 | The Ludovico Technique | Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy. |
The Mark | 79 | The Mark | Increases Damage and Speed, plus adds one Soul Heart. |
The Mind | 333 | The Mind | Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms. |
The Mulligan | 151 | The Mulligan | Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy. |
The Negative | 328 | The Negative | If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room. |
The Pact | 80 | The Pact | Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup. |
The Parasite | 104 | The Parasite | Isaac's tears split in two when they hit something. |
The Peeper | 155 | The Peeper | Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Fliesdamaging enemies it passes through. |
The Polaroid | 327 | The Polaroid | If the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest. |
The Relic | 98 | The Relic | Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms. |
The Sad Onion | 1 | The Sad Onion | Increases Tears by 0.7. |
The Small Rock | 90 | The Small Rock | Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1. |
The Soul | 335 | The Soul | Grants two soul hearts. Isaac now repels enemy projectiles. |
The Virus | 13 | The Virus | Inflicts poison to enemies who make contact with Isaac. Speed down. |
The Wafer | 108 | The Wafer | All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead. |
There's Options | 249 | There's Options | There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear. |
Thunder Thighs | 314 | Thunder Thighs | Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed. |
Tough Love | 150 | Tough Love | Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears. |
Virgo | 303 | Virgo | Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills". |
X-Ray Vision | 76 | X-Ray Vision | Reveals and opens all Secret Room and Super Secret Room entrances. |
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